PUBLICATIONS

Granzyme K activates the entire complement cascade. Donado CA, Theisen E, Zhang F, Nathan A, Fairfield ML, Rupani KV, Jones D, Johannes KP; Accelerating Medicines Partnership RA/SLE Network; Raychaudhuri S, Dwyer DF, Jonsson AH, Brenner MB. Nature 2025

Human intraepithelial mast cell differentiation and effector function are directed by TGF-β signaling. Derakhshan T, Hollers E, Perniss A, Ryan T, McGill A, Hacker J, Bergmark RW, Bhattacharyya N, Lee SE, Maxfield AZ, Roditi RE, Bankova L, Buchheit KM, Laidlaw TM, Boyce JA, Dwyer DF. J Clin Invest. 2025

Human nasal epithelial cells express IL-5Rα but not the co-receptor CSF2RB and do not signal to IL-5. Sohail A, Cho L, Hacker J, Bergmark RW, Lee SE, Maxfield A, Roditi RE, Dwyer DF, Buchheit KM, Laidlaw TM. Allergy 2024

Mast cells control lung type 2 inflammation via prostaglandin E₂-driven soluble ST2. Alhallak K, Nagai J, Zaleski K, Marshall S, Salloum T, Derakhshan T, Hayashi H, Feng C, Kratchmarov R, Lai J, Kuchibhotla V, Nishida A, Balestrieri B, Laidlaw T, Dwyer DF, Boyce JA. Immunity 2024

IL-4Rα signaling promotes barrier-altering oncostatin M and IL-6 production in aspirin-exacerbated respiratory disease. Chen CC, Buchheit KM, Lee PY, Brodeur KE, Sohail A, Cho L, Baloh CH, Balestrieri B, Derakhshan T, Feng C, Boyce JA, Dwyer DF, Laidlaw TM. J Allergy Clin Immunol 2024

TCF1-LEF1 co-expression identifies a multipotent progenitor cell (T_H2-MPP) across human allergic diseases. Kratchmarov R, Djeddi S, Dunlap G, He W, Jia X, Burk CM, Ryan T, McGill A, Allegretti JR, Kataru RP, Mehrara BJ, Taylor EM, Agarwal S, Bhattacharyya N, Bergmark RW, Maxfield AZ, Lee S, Roditi R, Dwyer DF, Boyce JA, Buchheit KM, Laidlaw TM, Shreffler WG, Rao DA, Gutierrez-Arcelus M, Brennan PJ. Nat Immunol 2024

Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment. Koganesawa M, Dwyer DF, Alhallak K, Nagai J, Zaleski K, Samuchiwal S, Hiroaki H, Nishida A, Hirsch TI, Brennan PJ, Puder M, Balestrieri B. Immunology 2024

Optimizing cryopreservation of nasal polyp tissue for cellular functional studies and single-cell RNA sequencing. Sohail A, Baloh CH, Hacker J, Cho L, Ryan T, Bergmark RW, Lee SE, Maxfield A, Roditi R, Dwyer DF, Buchheit KM, Laidlaw TM. Int Forum Allergy Rhinol 2024

The interweaved signatures of common-gamma-chain cytokines across immunologic lineages. Baysoy A, Seddu K, Salloum T, Dawson CA, Lee JJ, Yang L, Gal-Oz S, Ner-Gaon H, Tellier J, Millan A, Sasse A, Brown B, Lanier LL, Shay T, Nutt S, Dwyer D, Benoist C, Immunological Genome Project Consortium. J Exp Med 2023

IgG:FcγRIIb signals block effector programs of IgE:FcεRI-activated mast cells but spare survival pathways. Kanagaratham C, Derakhshan T, El Ansari YS, Furiness KN, Hollers E, Keldsen M, Oettgen HC*, Dwyer DF*. J Allergy Clin Immunol. *Equal contribution

Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation, and activation that persists in remission. Ben-Baruch Morgenstern N, Ballaban AY, Wen T, Shoda T, Caldwell JM, Kliewer K, Felton JM, Abonia JP, Mukkada VA, Putnam PE, Bolton SM, Dwyer DF*, Barrett NA*, Rothenberg ME*. J Allergy Clin Immunol. *Equal Contribution

Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease. Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM. J Allergy Clin Immunol.

COVID-19 infection in patients with mast cell disorders including mastocytosis does not impact mast cell activation symptoms. Giannetti MP, Weller E, Alvarez-Twose I, Torrado I, Bonadonna P, Zanotti R, Dwyer DF, Foer D, Akin C, Hartmann K, Rama TA, Sperr WR, Valent P, Teodosio C, Orfao A, Castells M. J Allergy Clin Immunol Pract.

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation. Dwyer DF*, Ordovas-Montanes J*, Allon SJ, Buchheit KM, Vukovic M, Derakhshan T, Feng C, Lai J, Hughes TK, Nyquist SK, Giannetti MP, Berger B, Bhattacharyya N, Roditi RE, Katz HR, Nawijn MC, Berg M, van den Berge M, Laidlaw TM, Shalek AK*, Barrett NA*, Boyce JA*. Sci Immunol. *Equal contribution

Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation. Derakhshan T, Samuchiwal SK, Hallen N, Bankova LG, Boyce JA, Barrett NA, Austen KF, Dwyer DF. J Exp Med.

IL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease.Buchheit KM, Dwyer DF, Ordovas-Montanes J, Katz HR, Lewis E, Vukovic M, Lai J, Bankova LG, Bhattacharyya N, Shalek AK, Barrett NA, Boyce JA, Laidlaw TM. J Allergy Clin Immunol. 2020

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.  Ziegler CGK*, Allon SJ*, Nyquist SK, Mbano IM*, Miao VN*, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH 2nd, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK*, Ordovas-Montanes J*. Cell. 2020 *Equal contribution

The cysteinyl leukotriene 3 receptor regulates airway brush cell expansion leading to type 2 inflammation. Bankova LG, Dwyer DF, Yoshimoto E, Ualiyeva S, McGinty JW, Raff H, von Moltke J, Kanaoka Y, Frank Austen K, Barrett NA. Sci Immunol 2018.

Allergic inflammatory memory in human respiratory progenitor epithelial cells. Ordovas-Montanes J*, Dwyer DF*, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH 2nd, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA*, Shalek AK*. Nature 2018. *Equal contribution

Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Dwyer DF, Barrett NA, Austen KF, Immunological Genome Project Consortium. Nat Immunol 2016.

Carbonic anhydrase enzymes regulate mast cell-mediated inflammation. Henry EK, Sy CB, Inclan-Rico JM, Espinosa V, Ghanny SS, Dwyer DF, Soteropoulos P, Rivera A, Siracusa MC; J Exp Med 2016.

Maturation of mast cell progenitors to mucosal mast cells during allergic pulmonary inflammation in mice. Bankova LG, Dwyer DF, Liu AY, Austen KF, Gurish MF, Mucosal Immunol 2015.

B Cells Regulate CD4+ T cell responses to papain following BCR-independent papain uptake. Dwyer DF, Woodruff MC, Carroll MC, Austen KF, Gurish MF; J Immunol 2014.